Semaglutide (the same ingredient in Wegovy & Ozempic) and Tirzepatide (the same ingredient in Zepbound & Mounjaro) are self-injectable weight loss medications that can support long-term weight management.Semaglutide is a mono-agonist medication targeting the GLP-1 gut hormone. Tirzepatide is a dual agonist that targets the GLP-1 receptors and the GIP receptors. When these receptors are triggered, they signal the brain, “I am satiated (full).” They also impact the dopamine-based reward center in the brain, blocking the reward cycle of cravings. They silence the “food noise” in the brain, allowing you to pass on the items that you were previously too weak to pass on.
Semaglutide has a slightly less robust effect on weight loss than Tirzepatide and, in my experience, seems to have slightly more uncomfortable GI side effects than Tirzepatide does. In our office, we have vetted many compounding pharmacies to find the best, safest product at the lowest price, and the pharmacy we are now using is fabulous. The medications work better, have fewer side effects, and are slightly lower priced per milligram than others we have worked with.
We are currently offering Tirzepatide. We have found it to be better tolerated, more efficacious and safe. Our patients have been more successful, more rapidly, with Tirzepatide.Studies have recently reported potentially positive effects beyond reducing diabetes, high blood pressure, and high cholesterol. These medications are thought to have a neuroprotective and anti-inflammatory effect throughout the body. I anticipate much more information soon regarding the many ways these medications are beneficial beyond what we know now.